VIRUSMYTH HOMEPAGE

Progress in Nucleic Acid Research and Molecular Biology
43:135-204, 1992


Latent Viruses and Mutated
Oncogenes: No Evidence
for Pathogenicity

PETER H. DUESBERG AND
JODY R. SCHWARTZ

Department of Molecular and Cell Biology
University of California at Berkeley
Berkeley, California 94720



Acknowledgments

We thank J. Michael Bishop (San Francisco), Michael Botchan, Eli Canaani (Philadelphia), Asit Chakraborty, Bryan J. Ellison, David Goodrich (San Antonio), Robert Hoffman (San Diego), Ruhong Li, Ranu Nandi, Philip Rosen (Boston), Harry Rubin, Janie Stone, and Charles Thomas, Jr. (San Diego) for critical reviews, critical information, or both; Jane A. Byrd for the final draft of this manuscript and its many precursors; and Cell for providing a free copy of Human Retrovirology: HTLV (176) for a book review that was not published. P.H.D. is supported by Outstanding Investigator Grant 5-R35-CA39915-07 from the National Cancer Institute.

References

1. J.D. Watson, N.H. Hopkins, W.R. Jeffrey, J.A. Steitz and A.M. Weiner, Molecular Biology of the Gene. Benjamin, New York, 1987.

2. P.H. Duesberg, Cancer Res. 47, 1199 (1987).

3. A.S. Evans, Viral Infections of Humans, Epidemiology and Control. Plenum, New York, 1989.

4. J.M. Bishop, ARB 52, 301 (1983).

5. H.E. Varmus, ARGen 18, 533 (1984).

6. R. Weiss, N. Teich, H. Varmus and J. Coffin, Molecular Biology of RNA Tumor Viruses. CSHLab, Cold Spring Harbor, New York, 1985.

7. J.M. Bishop, Science 235, 305 (1987).

8. G.M. Cooper, Oncogenes. Jones & Bartlett, Boston, 1990.

9. J.M. Bishop, Cell 64, 235 (1991).

10. F. Fenner, B.R. McAuslan, C.A. Mims, J. Sambrook and D.O. White, The Biology of Animal Viruses. Academic Press, New York, 1974.

11. B.A. Freeman, Burrows Textbook of Microbiology. Saunders, Philadelphia, 1979.

12. C. Mims and D.O. White, Viral Pathogenesis and Immunology. Blackwell, Oxford, 1984.

13. J. Tooze, DNA Tumor Viruses, Molecular Biology of Tumor Viruses. CSHLab, Cold Spring Harbor, New York, 1981.

14. W. Blattner, R.C. Gallo and H.M. Temin, Science 241, 514 (1988).

15. R. Weiss and H. Jaffe, Nature 345, 659 (1990).

16. H.C. Pitot, Fundamentals of Oncology. Dekker, New York, 1986.

17. R.J. Huebner and G. Todaro, PNAS 64, 1087 (1969).

18. P.H. Duesberg and P.K. Vogt, PNAS 67, 1673 (1970).

19. G.S. Martin and P.H. Duesberg, Virology 47, 494 (1972).

20. E.M. Scolnick, F. Rands, P. Williams and W.P. Parks, J. Virol. 12, 458 (1973).

21. E.M. Scolnick and W.P. Parks, J. Virol. 13, 1211 (1974).

22. N. Tsuchida, R.V. Gilden and M. Hatanaka, PNAS 71, 4503 (1974).

23. C.J. Tabin, S.M. Bradley, C.I. Bargmann, R.A. Weinberg, A.G. Papageorge, E.M. Scolnick, R. Dhar, D.R. Lowy and E.H. Chang, Nature 300, 143 (1982).

24. J.M. Bishop, Adv. Cancer Res. 37, 1 (1982).

25. J.M. Bishop, Cell 23, 5 (1981).

26. E.P. Reddy, R.K. Reynolds, E. Santos and M. Barbacid, Nature 300, 149 (1982).

27. J. Logan and J. Cairns, Nature 300, 104 (1982).

28. B. Vogelstein, E.R. Fearon, B.A. Stanley, R. Hamilton, S.E. Kern, A.C. Preisinger, M. Leppert, Y. Nakamura, R. White, A.M.M. Smits and J.L. Bos, N. Engl. J. Med. 319, 525 (1988).

29. G. Klein, Cell 12, 311 (1983).

30. P. Leder, J. Battey, G. Lenoir, C. Moulding, P. Huntington, T. Stewart and R. Taub, Science 222, 765 (1983).

31. W.S. Hayward, B.G. Neel and S.M. Astrin, Nature 290, 475 (1981).

32. G.S. Payne, J.M. Bishop and H.E. Varmus, Nature 295, 209 (1982).

33. A. De Klein, A.G. van Kessel, G. Grosveld, C.R. Bartram, A. Hagemeijer, D. Bootsma, N.K. Spurr, N. Heisterkamp, J. Groffen and J.R. Stephenson, Nature 300, 765 (1982).

34. R. Nusse and H.E. Varmus, Cell 31, 99 (1982).

35. P.H. Duesberg, Nature 304, 219 (1983).

36. P.H. Duesberg, Science 228, 669 (1985).

37. P.H. Duesberg, PNAS 84, 2117 (1987).

38. P.H. Duesberg, R.-P. Zhou and D.W. Goodrich, Ann. N.Y. Acad. Sci. 567, 259 (1989).

39. K. Cichutek and P.H. Duesberg, PNAS 83, 2340 (1986).

40. R.-P. Zhou and P.H. Duesberg, PNAS 85, 2924 (1988).

41. K. Cichutek and P.H. Duesberg, J. Virol. 63, 1377 (1989).

42. R.-P. Zhou and P.H. Duesberg, PNAS 86, 7721 (1989).

43. H. Zhou and P.H. Duesberg, PNAS 87, 9128 (1990).

44. A.K. Chakraborty, K. Cichutek and P.H. Duesberg, PNAS 88, 227 (1991).

45. A. Knudson, Jr., Cancer Res. 45, 1437 (1985).

46. E. Stanbridge, Science 247, 12 (1990).

47. L.A. Loeb, Cancer Res. 51, 3075 (1991).

48. A.C. Christensen, Nature 351,600 (1991).

49. Institute of Medicine, Confronting AIDS. National Academy Press, Washington, D.C., 1986.

50. Centers for Disease Control, JAMA 258, 1143 (1987).

51. Institute of Medicine, Confronting AIDS-Update 1988. National Academy Press, Washington, D.C., 1988.

52. Centers for Disease Control, HIV/AIDS Surveillance. (Year-end edition) U.S. Department of Health and Human Services, Atlanta, January 1992.

53. P.H. Duesberg, PNAS 86, 755 (1989).

54. P.H. Duesberg, PNAS 88, 1575 (1991).

55. National Commission on AIDS, The Twin Epidemics of Substance Use and HIV. National Commission on AIDS, Washington, D.C., July 1991.

56. M. Marmor, A.E. Friedman-Kien, L. Laubenstein, R.D. Byrum, D.C. William, S. D'Onofrio and N. Dubin, Lancet 1, 1083 (1982).

57. Centers for Disease Control, N. Engl. J. Med. 306, 248 (1982).

58. H.W. Haverkos, P.F. Pinsky, D.P. Drotman and D.J. Bregman, J. Sexually Transmitted Dis. 12, 203 (1985).

59. J. Lauritsen and H. Wilson, Death Rush, Poppers and AIDS. Pagan, New York, 1986.

60. P.H. Duesberg, Res. Immunol. 141, 5 (1990).

61. R. Root-Bernstein, Perspect. Biol. Med. 33, 480 (1990).

62. J. Rappoport, AIDS INC. Human Energy Press, San Bruno, California, 1988.

63. J. Adams, AIDS: The HIV Myth. St. Martin's, New York, 1989.

64. H.W. Haverkos, in Health Hazards of Nitrite Inhalants (H. W. Haverkos and J.A. Dougherty, eds.), NIDA Res. Monogr. 83, p. 96. National Institute on Drug Abuse, Washington, D.C., 1988.

65. V. Beral, T.A. Peterman, R.L. Berkelman and H.W. Jaffe, Lancet 335, 123 (1990).

66. R.L. Stoneburner, D.C. Des Jarlais, D. Benezra, L. Gorelkin, J.L. Sotheran, S.R. Friedman, S. Schultz, M. Marmor, D. Mildvan and R. Maslansky, Science 242, 916 (1988).

67. M.M. Braun, B.I. Truman, B. Maguire, G.T. Di Ferdinando, Jr., G. Wormser, R. Broaddus and D.L. Morse, JAMA 261, 393 (1989).

68. N.A. Ettinger and R.J. Albin, Am. J. Med. 87, 664 (1989).

69. J.M. Pluda, R. Yarchoan, E.S. Jaffe, I.M. Feuerstein, D. Solomon, S. Steinberg, K. M. Wyvill, A. Raubitschek, D. Katz and S. Broder, Ann. Intern. Med. 113, 276 (1990).

70. D.D. Richman, M.A. Fischl, M.H. Grieco, M.S. Gottlieb, P.A. Volberding, O.L. Laskin, J.M. Leedom, J.E. Groopman, D. Mildvan, M.S. Hirsh and the AZT Collaborative Working Group, N. Engl. J. Med. 317, 192 (1987).

71. K. Smothers, AIDS Reader 1, 29 (1991).

72. R.M. Selik, J.W. Buehler, J.M. Karon, M.E. Chamberland and R.L. Berkelman, J. Acquired Immune Deficiency Syndr. 3, 73 (1990).

73. S. Vermund, J. NIH Res. 3, 77 (1991).

74. D.N. Lawrence, J.M. Jason, R.C. Holman and J.J. Murphy, in Heterosexual Transmission of AIDS (N.J. Alexander, H.L. Gabelnick and J.M. Spieler, eds.), p. 35. Wiley-Liss, New York, 1990.

75. B.J. Van Voorhis, A. Martinez, K. Mayer and D.J. Anderson, Fertil. Steril. 55, 588 (1991).

76. R.C. Gallo, Virus Hunting-AIDS, Cancer, and the Human Retrovirus: A Story of Scientific Discovery. Basic Books, New York, 1991.

77. D. Baltimore and M.B. Feinberg, N. Engl. J. Med. 321, 1673 (1990).

78. R.C. Gallo and L. Montagnier, Sci. Am. 259(4), 41 (1988).

79. G. Kolata, Science 235, 1463 (1987).

80. P.A. Volberding and the AIDS Clinical Trial Group, N. Engl. J. Med. 322, 941 (1990).

80a. R. Yarchoan, J.M. Pluda, C.-F. Perno, H. Mitsuya and S. Broder, Blood 78, 859 (1991).

81. M.E. St. Louis, G.A. Conway, C.R. Hayman, C. Miller, L.R. Peterson and T.J. Dondero, JAMA 266, 2387 ( 1991 ).

82. A.E. Williams, C.T. Fang and G. Sandler, in Human Retrovirology: HTLV (W. A. Blattner, ed.), p. 349. Raven, New York, 1990.

83. D.S. Burke, J.F. Brundage, M. Goldenbaum, M. Gardner, M. Peterson and V.R. Redfield, JAMA 263, 2074 (1990).

84. S.M. Schnittman, M.C. Psallidopoulos, H.C. Lane, L. Thompson, M. Baseler, F. Massari, C.H. Fox, N.P. Salzman and A. Fauci, Science 245, 305 (1989).

85. M. Lemaitre, D. Guetard, Y. Henin, L. Montagnier and A. Zerial, Res. Virol. 141, 5 (1990).

86. E. Langhoff, J. McElrath, H.J. Bos, J. Pruett, A. Granelli-Piperno, Z.A. Cohn and R. M. Steinman, J. Clin. Invest. 84, 1637 (1989).

87. E. Rubenstein, Science 948, 1494 (1990).

88. P.H. Duesberg, N. Engl. J. Med. 322, 1466 (1990).

89. D.P. Hamilton, Science 254, 941 (1991).

90. J. Cohen, Science 254, 946 (1991).

91. E.S. Daar, T. Moudgil, R.D. Meyer and D.D. Ho, N. Engl. J. Med. 324, 961 (1991).

92. S.J. Clark, M.S. Saag, W.D. Decker, S. Campbell-Hill, J.L. Roberson, P.J. Veldkamp, J.C. Kappes, B.H. Hahn and G.M. Shaw, N. Engl. J. Med. 324, 954 (1991).

93. M.S. Goldsmith, JAMA 264, 265 (1990).

94. J. Maddox, Nature 353, 297 (1991).

95. J. Maddox, Nature 354, 103 (1991).

96. J. Palca, Science 254, 376 (1991).

97. S.O. Aral and K.K. Holmes, Sci. Am. 264, 62 (1991).

98. F.N. Judson, K.A. Penley, M.E. Robinson and J.K. Smith, Am.J. Epidemiol. 112, 836 (1980).

99. E. Papadopulos-Eleopulos, Med. Hypotheses 25, 151 (1988).

100. H. Albonico, Schweiz. Ærztezeit. 72, 379 (1991).

101. H.W. Haverkos and J.A. Dougherty (eds.), Health Hazards of Nitrite Inhalants, NIDA Res. Monogr. 83. National Institute on Drug Abuse, Washington, D.C., 1988.

102. W.R. Holub, Am. Clin. Prod. Rev. 7, 28 (1988).

103. P.H. Duesberg, Biomed. Pharmacother. 46, 3 (1992).

104. World Health Organization, WHO-Report No. 26, AIDS Surveillance in Europe, Geneva, June 1990.

105. D.G. Ostrow, M.J. Van Raden, R. Fox, L.A. Kingsley, J. Dudley, R.A. Kaslow and the Multicenter AIDS Cohort Study, AIDS 4, 759 (1990).

106. W.A. Blattner, R.J. Biggar, S.H. Weiss, J.W. Clark and J.J. Goedert, Cancer Res. 45, 4598 (1985).

107. W.W. Darrow, D.F. Echenberg, H.W. Jaffe, P.M. O'Malley, R.H. Byers, J.P. Getcheil and J.W. Curran, Am. J. Public Health 77, 479 (1987).

108. S.H. Weiss, JAMA 261,607 (1989).

109. C.F. Turner, H.G. Miller and L.E. Moses, AIDS, Sexual Behavior and Intravenous Drug Use. National Academy Press, Washington, D.C., 1989.

110. C.A. Raymond, JAMA 259, 329 (1988).

111. San Francisco Department of Public Health, Gay Men, Lesbians and Their Alcohol and Other Drug Use: A Review of the Literature. Department of Public Health, San Francisco, September 1991.

112. R. Shilts, And the Band Played On. St. Martin's, New York, 1985.

113. G.R. Newell, M.R. Spitz and M.B. Wilson, in Health Hazards of Nitrite Inhalants (H. W. Haverkos and J.A. Doughexty, eds.), NIDA Res. Monogr. 83, p. 1. National Institute on Drug Abuse, Washington, D.C., 1988.

114. S.S. Mirvish and H.W. Haverkos, N. Engl. J. Med. 317, 1603 (1987).

115. San Francisco Department of Public Health, San Francisco Lesbian, Gay and Bisexual Substance Abuse Needs Assessment. Department of Public Health, San Francisco, August 1991.

116. W.R. Lange, E.M. Dax, C.A. Haertzen, F.R. Snyder and J.H. Jaffe, in Health Hazards of Nitrite Inhalants (H. W. Haverkos and J.A. Dougherty, eds.), NIDA Res. Monogr. 83, p. 86. National Institute on Drug Abuse, Washington, D.C., 1988.

117. P. Drotman and H.W. Haverkos, in Co-factors in HIV-1 Infection and AIDS (R. R. Watson, ed.), p. 231. CRC Press, Boca Raton, Florida, 1990.

118. H.W. Haverkos, J. Acquired Immune Deficiency Syndr. 3, S47 (1990).

119. M.A. Fischl, D.D. Richman, M.H. Grieco, M.S. Gottlieb, P.A. Volberding and the AZT Collaborative Working Group, N. Engl. J. Med. 317, 185 (1987).

120. Editorial, Lancet 335, 821 (1990).

121. R. Yarchoan and S. Broder, N. Engl. J. Med. 316, 557 (1987).

122. Multicenter AIDS Cohort Study of the National Institutes of Health, LA Men's Study (LAMS) Newsletter. National Institutes of Health Los Angeles, March 1991.

123. E. Dournon and the Claude Bernard Hospital AZT Study Group, Lancet 2, 1297 (1988).

124. P.S. Gill, M. Rarick, R.K. Byrnes, D. Causey, C. Loureiro and A.M. Levine, Ann. Intern. Med. 107, 502 (1987).

125. C.E. Swanson, D.A. Cooper and the Australian Zidovudine Study Group, AIDS 4, 749 (1990).

126. M. Till and K.B. MacDonnell, Ann. Intern. Med. 113, 492 (1990).

127. D.A. eorard and B.J. Guilodd, Lancet 1, 1050 (1988).

128. L.J. Bessen, J.B. Greene, L.E. Seitzman and H. Weinberg, N. Engl. J. Med. 318, 708 (1988).

129. S.S. Cohen, N. Engl. J. Med. 317, 629 (1987).

130. R. Yarchoan and S. Broder, N. Engl. J. Med. 317, 630 (1987).

131. H.I. Chernov, Document on New Drug Application 19-655. Food and Drug Administration, Washington, D.C., 1986.

132. L.P. Elwell, R. Ferone, G.A. Freeman, J.A. Fyfe, J.A. Hill, P.H. Ray, C.A. Richards, S. C. Singer, C.B. Knick, J.L. Rideout and T.P. Zimmerman, Antimicrob. Agents Chemother. 31, 274 (1987).

133. I. Reinvang, S.S. Froland, N.R. Karlsen and A.J. Lundervold, AIDS 5, 228 (1991).

134. J. Nelson, J. Rodack, R. Fitz and A.B. Smith, Natl. Enquirer 66 (20), 6 (Dec. 10, 1991).

135. J. Lauritsen, Poison by Prescription-The AZT Story. Asklepios, New York, 1990.

136. H.W. Jaffe, D.J. Bregman and R.M. Selik, J. Inf. Dis. 148, 339 (1988).

137. M.S. Gottlieb, H.M. Schanker, P.T. Fan, A. Saxon, J.D. Weisman and J. Pozalski, Morb. Mort. Weekly Rep. 30, 250 (1981).

138. H.W. Haverkos, in Psychological, Neuropsychiatric and Substance Abuse Aspects of AIDS (T. P. Bridge et al, eds.), p. 165. Raven, New York, 1988.

139. R. Weber, W. Ledergerber, M. Opravil, W. Siegenthaler and R. Lüthy, Br. Med. J. 301, 1361 (1990).

140. D. Des Jarlais, S. Friedman, M. Marmot, H. Cohen, D. Mildvan, S. Yancovitz, U. Mathut, W. El-Sadr, T.J. Spira and J. Gatbet, AIDS 1, 105 (1987).

140a. J.D. Hamilton, P.M. Hartigan, M.S. Simberkoff et al. and the Veterans Affairs Cooperative Study Group on AIDS Treatment, N. Engl. J. Med. 326, 437 (1992).

141. A.R. Moss, D. Osmond and P. Bacchetti, Science 242, 997 (1988).

142. G.F. Lemp, S.F. Payne, G.W. Rutherford, N.A. Hessol, W. Winkelstein, Jr., J.A. Wiley, A.R. Moss, R.E. Chaisson, R.T. Chen, D.W. Feigal, P.A. Thomas and D. Werdegar, JAMA 263, 1497 (1990).

143. B.S. Peters, E.J. Beck, D.G. Coleman, M.J.H. Wadsworth, O. McGuinness, J.R.W. Harris and A. J. Pinching, Br. Med.J. 302, 203 (1991).

144. O. Stutman, Adv. Cancer Res. 22, 261 (1975).

145. M. Scolaro, R. Durham and G. Pieczenik, Lancet 337, 731 (1991).

146. P.A. Selwyn, A.R. Feingold, D. Hartel, E.E. Schoenbaum, M.H. Adderman, R.S. Klein and S.H. Freidland, AIDS 2, 267 (1988).

147. R.M. Donahoe, C. Bueso-Ramos, F. Donahoe, J.J. Madden, A. Falek, J.K.A. Nicholson and P. Bokos, Ann. N.Y. Acad. Sci. 496, 711 (1987).

148. S. Savona, M.A. Nardi, E.T. Lenette and S. Karpatkin, Ann. Intern. Med. 102, 737 (1985).

149. G.H. Mientjes, F. Miedema, E.J. van Ameijden, A.A. van den Hock, P.T.A. Schellekens, M.T. Roos and R.A. Coutinho, AIDS 5, 35 (1991).

150. D.C. Des Jarlais, S.R. Friedman and W. Hopkins, in AIDS and IV Drug Abusers; Current Perspectives (R. P. Galea, B.F. Lewis and L. Baker, eds.), p. 97. National Health Publishing, Owings Mills, Maryland, 1988.

151. P. Espinoza, I. Bouchard, C. Buffet, V. Thiers, J. Pillot and J.P. Etienne, Gastroenterol. Clin. Biol. 11, 288 (1987).

152. A.E. Friedman-Kien, B.R. Saltzman, Y. Cao, M.S. Nestor, M. Mirabile, J.J. Li and T.A. Peterman, Lancet 335, 168 (1990).

153. T. Koch, CDC AIDS Weekly, p. 9 (July 30, 1990).

154. P.H. Duesberg, Scientist (Philadelphia, PA), vol. 5, p. 12 (July 8, 1991).

155. W.D. Lerner, Am. J. Med. 87, 661 (1989).

156. J. Levy, Nature 333, 519 (1988).

157. National Institute on Drug Abuse, Trends in Drug Abuse Related Hospital Emergency Room Episodes and Medical Examiner Cases for Selected Drugs: DAWN 1976-1985. National Institute on Drug Abuse, Bethesda, Maryland, 1987.

158. H.M. Ginzburg, in AIDS and IV Drug Abusers; Current Perspectives (R. P. Galea, B.F. Lewis and L. Baker, eds.), p. 61. National Health Publishing, Owings Mills, Maryland, 1988.

159. D.P. Francis, in The AIDS Epidemic (K. M. Cahill, ed.), p. 137. St. Martin's, New York, 1983.

160. Q.-L. Choo, A.J. Weiner, L.R. Overby, G. Kuo, M. Houghton and D.W. Bradley, Br. Med. Bull. 46, 423 (1990).

161. H.J. Alter, P.V. Holland, R.H. Purcell and H. Popper, Lancet 1, 459 (1978).

162. E. Tabor, J.A. Drucker, J.H. Hoofnagle, M. April, R.J. Gerety, L.B. Seeff, D.R. Jackson and L.F. Barker, Lancet 1, 463 (1978).

163. A.J. Weiner, G. Kuo, D.W. Bradley, G. Bonino, G. Saracco, C. Lee, J. Rosenblatt, Q.-L. Choo and M. Houghton, Lancet 335, 1 (1990).

164. C.H. Andrewes, J. Gen. Microbiol. 204, 140 (1965).

165. J.H. Connolly, I.V. Allen, L.J. Hurwitz and J.H.D. Millar, Lancet 1, 542 (1967).

166. H. Koprowski, in Slow Virus Infections of the Central Nervous System (V. ter Meulen and M. Katz, eds.), p. 152. Springer, New York, 1977.

167. R. Catteano, G. Rebmann, K. Baczko, V. ter Meulen and M.A. Billeter, Virology 160, 523 (1987).

168. R. Catteano, A. Schmid, D. Eschie, K. Baczko, V. ter Meulen and M.A. Billeter, Cell 55, 257 (1988).

169. G.M. Shaw, M.E. Harper, B.H. Hahn, L.G. Epstein, D.C. Gajdusek, R.W. Price, B.A. Navia, C.K. Petito, C.J. O'Hara, E .-S. Cho, J.M. Oleske, F. Wong-Staal and R. C. Gallo, Science 227, 177 (1985).

170. H. Rubin and H. Temin, Virology 7, 75 (1958).

171. D.C. Gajdusek, Science 197, 943 (1977).

172. D.C. Gajdusek, C.J. Gibbs, Jr., and M. Alpers, Nature 209, 794 (1966).

173. N. Stahl and S.B. Prusiner, FASEB J. 5, 2799 (1991).

174. G. Kolata, Science 232, 1497 (1986).

175. B.J. Poiesz, F.W. Ruscetti, A.F. Gazdar, P.A. Bunn, J.D. Minna and R.C. Gallo, PNAS 77, 7415 (1980).

176. W.A. Blattner, in Human Retrovirology: HTLV (W. A. Blattner, ed.), p. 251. Raven, New York, 1990.

177. P.H. Levine, in Human Retrovirology: HTLV (W. A. Blattner, ed.), p. 469. Raven, New York, 1990.

178. C. Bartholomew, F. Cleghorn and W.A. Blattner, in Human Retrovirology: HTLV (W. A. Blattner, ed.), p. 237. Raven, New York, 1990.

179. M. Shimoyama, Y. Kaagami, K. Shimotohno, M. Miwa, K. Minato, K. Tobinai, K. Suemasu and T. Sugimura, PNAS 83, 4524 (1986).

180. K. Yagamuchi, T. Kiyokawa, G. Futami, T. Ishii and K. Takatsuki, in Human Retrovirology: HTLV (W. A. Blattner, ed.), p. 163. Raven, New York, 1990.

181. G. de The, O. Grout, A. Gessain and L. Lyon-Caen, in Human Retrovirology: HTLV (W. A. Blattner, ed.), p. 333. Raven, New York, 1990.

182. S. Hino, in Human Retrovirology: HTLV (W. A. Blattner, ed.), p. 363. Raven, New York, 1990.

183. E.L. Murphy, in Human Retrovirology: HTLV (W. A. Blattner, ed.), p. 295. Raven, New York, 1990.

184. K. Tajima, S.-I. Ito and the Tsushima ATL Study Group, in Human Retrovirology: HTLV (W. A. Blattner, ed.), p. 267. Raven, New York, 1990.

185. T. Okamoto, S. Mori, Y. Ohno, S. Tsugane, S. Watanabe, M. Shimoyama, K. Tajima, M. Miwa and K. Shimotohno, in Human Retrovirology: HTLV (W. A. Blattner, ed.), p. 307. Raven, New York, 1990.

186. A.C. Guyton, Textbook of Medical Physiology, p. 65. Saunders, Philadelphia, 1987.

187. A.G. Dalgleish andJ. Richardson, in Human Retrovirology: HTLV (W. Blattner, ed.), p. 45. Raven, New York, 1990.

188. K. Miyamoto, N. Tomita, A. Ishii, N. Miyamoto, H. Nonaka, T. Kondo, T. Sugihara, Y. Yawata, S. Tada, T. Tsubota, K. Kitajima and I. Kimura, Int. J. Cancer 40, 461 (1987).

189. M. Waldholz, Wall Street J., p. BI (Nov. 2, 1988).

190. A.A. Awa, in Chromosomes and Cancer (J. German, ed.), p. 637 Wiley, New York, 1974.

191. H. zur Hausen, Cancer Res. 49, 4677 (1989).

192. S. Heim, N. Mandahl and F. Mitelman, Cancer Res. 48, 5911 (1988).

193. P.C. Nowell, in Cancer: A Comprehensive Treatise (F. F. Becker, ed.), p. 1. Plenum, New York, 1982.

194. J. German (ed.), Chromosomes and Cancer. Wiley, New York, 1974.

195. D.A. Galloway and J.K. McDougall, Nature 302, 21 (1983).

196. C.E. Rogler, Curr. Top. Microbiol. Immunol. 168, 103 (1991).

197. American Cancer Society, Cancer Facts and Figures-1991. American Cancer Society, Washington, D.C., 1991.

198. W.C. Reeves, D. Caussy, L.A. Brinton, M.M. Brenes, P. Montalvan, B. Gomze, R. C. de Britton, E. Moorice, E. Gaitan, S.L. de Lao and W.E. RawIs, Int. J. Cancer 40, 450 (1987).

199. C. Ley, H.M. Bauer, A. Reingold, M.H. Schiffman, J.C. Chambers, C.J. Tashiro and M.M. Manos, JNCI 83, 997 (1991).

200. J.M. Friedman and P.J. Fialkow, Int. J. Cancer 17, 57 (1976).

201. E. Schwartz, U.K. Freese, L. Gissmann, W. Mayer, B. Roggenbuck, A. Stremlau and H. zur Hausen, Nature 314, 111 (1985).

202. M. Scheffner, K. Munger, J.C. Byrne and P.M. Howley, PNAS 88, 5523 (1991).

203. P. Rous, Science 157, 24 (1967).

204. L.A. Brinton, C. Schairer, W. Haenszel, P. Stolley, H.F. Lehman, R. Lovert and D. A. Savitz, JAMA 255, 3265 (1986).

205. T.D. Brock, The Emergence of Bacterial Genetics. CSHLab, Cold Spring Harbor, New York, 1990.

206. R.P. Beasley, C.-C. Lin, L.-Y. Hwang and C.-S. Chien, Lancet 2, 1129 (1981).

207. J.L. Melnick, in Viruses Associated with Human Cancer (L. A. Phillips, ed.), p. 337. Dekker, New York, 1983.

208. W. Szmuness, Prog. Med. Virol. 24, 40 (1978).

209. P. Tiollais, C. Pourcel and A. Dejean, Nature 317, 489 (1985).

210. D. Ganem and H.E. Varmus, ARB 56, 684 (1987).

211. W. Wang, W.T. London and M.A. Feitelson, Cancer Res. 51, 4971 (1991).

212. M.A. Epstein, B.G. Achong and Y.M. Barr, Lancet 1,702 (1964).

213. M.R. Gopal, B.J. Thomson, J. Fox, R.S. Tedder and R.W. Honess, Lancet 335, 1598 (1990).

214. J.S. Pagano, C.H. Huang and P. Levine, N. Engl. J. Med. 289, 1395 (1973).

215. G. Klein and E. Klein, Nature 315, 190 (1985).

216. F.G. Haluska, Y. Tsujimoto and C.M. Croce, ARGen 21,321 (1987).

217. P.H. Duesberg, K. Bister and P.K. Vogt, PNAS 74, 4320 (1977).

218. B. Sheiness and J.M. Bishop, J. Virol. 31, 514 (1979).

219. P. Mellon, A. Pawson, K. Bister, G.S. Martin and P.H. Duesberg, PNAS 75, 5874 (1978).

220. K. Alitalo, G. Ramsay, J.M. Bishop, S.O. Pfeifer, W.W. Colby and A.D. Levinson, Nature 306, 274 (1983).

221. S.R. Hahn, H.D. Abrams, L.R. Rohrschneider and R.N. Eisenman, Cell 34, 789 (1983).

222. S. Pfaff and P.H. Duesberg, J. Virol. 69., 3703 (1988).

223. G. Manolov and Y. Manolova, Nature 237, 33 (1972).

224. E.C. Douglas, 1. T. Magrath, E.C. Lee and J. Whang-Peng, Blood 55, 148 (1980).

225. R.J. Biggar, E.C. Lee, F.K. Nkrumah and J. Whang-Peng, JNCI 67, 769 (1981).

226. R. Berger, A. Bernheim, F. Sigaux, F. Valensi, M.-T. Daniel and G. Flandrin, Cancer Genet. Cytogenet. 15, 159 (1985).

227. C.M. Croce, W. Thierfelder, J. Erikson, K. Nishikura, J. Finan, G.M. Lenoir and P. C. Nowell, PNAS 80, 6922 (1983).

228. J. Erikson, A. ar-Rushidi, H.L. Drwinga, P.C. Nowell and C.M. Croce, PNAS 80, 820 (1983).

229. J. Erikson, K. Nishikura, A. ar-Rushidi, J. Finan, B. Emanuel, G. Lenoir, P.C. Nowell and C.M. Croce, PNAS 80, 7581 (1983).

230. E. Gelman, M.C. Psallidopoulous, T.S. Papas and R. Dalla-Favera, Nature 306, 799 (1983).

231. M. Davis, S. Malcolm and T.H. Rabbits, Nature 308, 286 (1984).

232. G.F. Hollis, K.F. Mitchell, J. Battey, H. Potter, R. Taub, G.M. Lenoir and P. Leder, Nature 307, 752 (1984).

233. P. Martin, C. Henry, F. Ferre, M. Duterque-Coquilland, C. Lagrou, J. Ghysdael, B.-Bebuire, D. Stehelin and S. Saule, EMBOJ. 5, 1529 (1986).

234. W.F. Lee, M. Schwab, D. Westaway and H.E. Varmus, MCBiol. 5, 3345 (1985).

235. M. Schwab, H.E. Varmus and J.M. Bishop, Nature 316, 160 (1985).

236. E. Sinn, W. Muller, P. Pattengale, I. Tepler, R. Wallace and P. Leder, Cell 49, 465 (1987).

237. G.M. Ramsay, G. Moscovici, C. Moscovici and J.M. Bishop, PNAS 87, 2101 (1990).

238. H. Land, L.F. Parada and R.A. Weinberg, Science 222, 771 (1983).

239. M. Zerlin, M.A. Julius, C. Cerni and K.B. Marcu, Oncogene 1, 19 (1987).

240. U.R. Rapp, J.L. Cleveland, T.N. Frederickson, K.L. Holmes, H.C. Morse III, H.W. Jansen, T. Patschinsky and K. Bister, J. Virol. 55, 23 (1985).

241. Y. Haupt, W.S. Alexander, G. Barri, S.P. Klinken and J.M. Adams, Cell 65, 753 (1991).

242. H.P. Koeffier and D.W. Golde, N. Engl. J. Med. 304, 1201 (1981).

243. H.P. Koeffier and D.W. Golde, N. Engl. J. Med. 304, 1269 (1981).

244. D. Sheer, in Introduction to the Cellular and Molecular Biology of Cancer (L. M. Franks and N. Teich, eds.), p. 229. Oxford University Press, Oxford, 1986.

245. P.H. Fitzgerald, C. McEwan, J. Fraser and M.E.J. Beard, Br. J. Haematol. 47, 571 (1981).

246. R.P. Gale and E. Canaani, PNAS 81, 5648 (1984).

247. J. Groffen, J.R. Stephenson, N. Heisterkamp, A. de Klein, C.R. Bartram and G. Grosveld, Cell 36, 93 (1984).

248. N. Heisterkamp, K. Stam, J. Groffen, A. de Klein and G. Grosveld, Nature 315, 758 (1985).

249. A. Bernards, C.M. Bubin, C.A. Westbrook, M. Paskind and D. Baltimore, MCBiol. 7, 3231 (1987).

250. H.T. Abelson and L.S. Babstein, Cancer Res. 30, 2213 (1970).

251. D. Baltimore, A. Shields, G. Otto, S. Goff, P. Besmer, O. Witte and N. Rosenberg, CSHSQB 44, 849 (1979).

252. G. Daley, R.A.V. Etten and D. Baltimore, Science 247, 824 (1990).

253. A. Srinivasan, E.P. Reddy and S.A. Aaronson, PNAS 78, 2077 (1981).

254. J.C. Young and O.N. Witte, MCBiol. 8, 4079 (1988).

255. I.K. Hariharan, A.W. Harris, M. Crawford, H. Abud, E. Webb, S. Cory and J. M. Adams, MCBiol. 9, 2798 (1989).

256. E.B. Hook and P.K. Cross, Ann. Hum. Genet. 51, 27 (1987).

257. E.B. Hook, in Aneuploidy: Etiology and Mechanisms (V. L. Dellarco, P.E. Voytek and A. Hollaender, eds.), p. 7. Plenum, New York, 1985.

258. National Cancer Institute, Annual Cancer Statistics Review. National Cancer Institute, Bethesda, Maryland, 1987.

259. T.G. Krontiris and G.M. Cooper, PNAS 78, 1181 (1981).

260. C. Shih, L.C. Padhy, M. Murray and R.A. Weinberg, Nature 290, 261 (1981).

261. E. Taparowsky, Y. Suard, O. Fasano, J. Shimizu, M. Goldfarb and M. Wigler, Nature 300, 762 (1982).

262. M. Barbacid, ARB 56, 779 (1987).

263. J.L. Bos, E.B. Fearon, S.B. Hamilton, M. Verlaan-de Vries, J.H. van Boom, A.J. van der Eb and B. Vogelstein, Nature 327, 293 (1987).

264. K. Forrester, C. Almoguera, K. Han, W. Grizzle and M. Perucho, Nature 327, 298 (1987).

265. S. Sagae, R. Kudo, N. Kuzumaki, T. Hisada, Y. Mugikura, T. Nihei, T. Takeda and M. Hashimoto, Cancer 66, 295 (1990).

266. K. Fujita, N. Ohuchi, T. Yao, M. Okumura, Y. Fukushima, Y. Kanakura, Y. Kitamura and J. Fujita, Gastroenterology 92, 1339 (1987).

267. M. Goyette, C.J. Petroploulos, P.R. Shank and N. Fausto, Science 219, 510 (1983).

268. C.J. Tabin and R.A. Weinberg, J. Virol. 53, 260 (1985).

269. E.J. Stanbridge, ARGen 24, 615 (1990).

270. T.H. Rabbits, P.H. Hamlyn and R. Baer, Nature 306, 760 (1983).

271. D. Westaway, G. Payne and H.E. Varmus, PNAS 81,643 (1984).

272. J. Marx, Science 251, 1317 (1991).

273. J.M. Horowitz, D.W. Yandell, S.-H. Park, S. Canning, P. Whyte, K. Buchkovich, E. Harow, R. Weinberg and T.P. Dryja, Science 243, 937 (1989).

274. R. Bookstein, J.-Y. Shew, P.-L. Chen, P. Scully and W.-H. Lee, Science 247, 712 (1990).

275. T. Hunter, Cell 49, 1 (1987).

276. R. Sager, K. Tanaka, C.C. Lau, Y. Ebina and A. Anisowicz, PNAS 80, 7601 (1983).

277. J. Cairns, Cancer Science and Society. Freeman, San Francisco, 1978.

278. B. Lewin, Genes IV. Oxford University Press, Oxford, 1990.

279. P.H. Seeburg, W.W. Colby, P.J. Capon, D.V. Goeddel and A.D. Levinson, Nature 312, 71 (1984).

280. A. Balmain, M. Ramsden, G.T. Bowden and J. Smith, Nature 307, 658 (1984).

281. S.H. Reynolds, S.J. Stowers, R.R. Maronpot, M.W. Anderson and S.A. Aaronson, PNAS 83, 33 (1986).

282. J. Leon, H. Kamino, J.J. Steinberg and A. Pellicer, MCBiol. 8, 786 (1988).

283. H. Hirai, Y. Koybayashi, H. Mano, K. Hagiwara, Y. Maru, M. Omine, H. Mizoguchi, J. Nishida and F. Takaku, Nature 337, 430 (1987).

284. E. Liu, B. Hjelle, R. Morgan, F. Hecht and J.M. Bishop, Nature 330, 186 (1987).

285. T.J. Velu, W.C. Vass, D.R. Lowy and P.E. Tambourin, J. Virol. 63, 1384 (1989).

286. K. Brown, B. Bailleul, M. Ramsden, F. Fee, R. Krumlauf and A. Balmain, Mol. Carcinogenesis 1, 161 (1988).

287. T.Y. Shih and E. Scolnick, Adv. Viral Oncol. 1, 135 (1982).

287a. R.A. Weinberg, Science 254, 1138 (1991).

288. J. Stone, T. De Lange, G. Ramsay, E. Jakobovits, J.M. Bishop, H. Varmus and W. Lee, MCBiol. 7, 1697 (1987).

289. H.E. Ruley, Cancer Cells 2, 258 (1990).

290. M.P. Goldfarb and R.A. Weinberg, J. Virol. 38, 125 (1981).

291. S.P. Goff, C.J. Tabin, J.Y.-J. Wang, R. Weinberg and D. Baltimore, J. Virol. 41,271 (1982).

292. D. Robbins, S. Ripley, A. Henderson and R. Axel, Cell 23, 29 (1981).

293. M. Perucho, D. Hanahan and M. Wigler, Cell 22, 309 (1980).

294. H. Rubin and K. Xu, PNAS 86, 1860 (1989).

295. D.A. Spandidos and N.M. Wilkie, Nature 310, 469 (1984).

296. I. Nishisho, Y. Nakamura, H. Miyoshi, Y. Miki, H. Ando, A. Horii, K. Koyama, J. Utsunomiya, S. Baba, P. Hedge, A. Markham, A.J. Krush, G. Petersen, S.R. Hamilton, M.C. Nilbert, D.B. Levy, T.M. Bryan, A.C. Preisinger, K.J. Smith, L.-K. Su, K.W. Kinzler and B. Vogelstein, Science 253, 665 (1991).

297. F. McCormick, Cancer Cells 1, 56 (1989).

298. J.C. Cohen and H.E. Varmus, Nature 278, 418 (1979).

299. P. Bentvelzen, BBA 355, 236 (1974).

300. D.H. Moore, C.A. Long, A.B. Vaidya, J.B. Sheffield, A.S. Dion and E.Y. Lasfargues, Adv. Cancer Res. 29, 347 (1979).

301. H.B. Andervont, JNCI 1, 147 (1940).

302. H.B. Andervont, Ann. N.Y. Acad. Sci. 54, 1004 (1952).

303. M.B. Gardner and S. Rasheed, Int. Rev. Exp. Pathol. 23, 209 (1982).

304. J. Mester, E. Wagenaar, M. Sluyser and R. Nusse, J. Virol. 61, 1073 (1987).

305. P.R. Etkind, J. Virol. 63, 4972 (1989).

306. C. Dickson, R. Smith, S. Brookes and G. Peters, Cell 37, 529 (1984).

307. D. Gallahan and R. Callahan, J. Virol. 61, 66 (1987).

308. R. Nusse, Trends Genet. 4, 291 (1988).

309. V.K. Pathak, R. Strange, L.J.T. Young, D.W. Morris and R.D. Cardiff, JNCI 78, 327 (1987).

310. R. Nusse, A. van Ooyen, D. Cos, Y.K. Fung and H.E. Varmus, Nature 307, 131 (1984).

311. W.F. Benedict, A. Banerjee, C. Mark and A.L. Murphree, Cancer Genet. Cytogenet. 10, 311 (1983).

312. H.A. Gardener, B.L. Gallie, L.A. Knight and R.A. Phillips, Cancer Genet. Cytogenet. 6, 201 (1982).

313. S.H. Friend, R. Bernards, S. Rogelj, R.A. Weinberg, J.M. Rapaport, D.M. Albert and T.P. Dryja, Nature 323, 643 (1986).

314. A.D. Goddard, H. Balakier, M. Canton, J. Dunn, J. Squire, E. Reyes, A. Becket, R. A. Phillips and B.L. Gallie, MCBiol. 8, 2082 (1988).

315. J.M. Dunn, R.A. Phillips, X. Zhu, A. Becker and B.L. Gallie, MCBiol. 9, 4596 (1989).

316. F.J. Kaye, R.A. Kratzke, J.L. Gerster and J.M. Horowitz, PNAS 87, 6922 (1990).

317. R.E. Hollingsworth and W.-H. Lee, JNCI 83, 91 (1991).

318. H.-J. Xu, J. Sumegi, S.-X. Hu, A. Banerjee, E. Uzvolgyi, G. Klein and B. Benedict, Cancer Res. 51, 4481 (1991).

318a. M.M. Muncaster, B.L. Cohen, R.A. Phillips and B.L. Gallie, Cancer Res. 52, 654 (1992).

319. S.J. Baker, E.R. Fearon, J.K.V. Willson and B. Vogelstein, Science 249, 912 (1990).

319a. L.A. Donehower, M. Harvey, B.L. Siagle, M.J. McArthur, C.A. Montgomery Jr., J.S. Butel and A. Bradley, Nature 356, 215 (1992).

320. T. Puck, The Mammalian Cell as a Microorganism. Holden-Day, San Francisco, 1972.

321. H. Petersson and F. Mitelman, Hereditas 102, 33 (1985).

322. A. Yen, S. Chandler and S. Sturzenegger-Varvayanis, Exp. Cell Res. 192, 289 (1991).

323. A. Haase, A. Evangelista, H. Minnigan, S. Maroushek, A. Larson, E. Retzel, D. McFarlin, S. Jackobson and C. Bartholomew, in Human Retrovirology: HTLV (W. A. Blattner, ed.), p. 15. Raven, New York, 1990.

324. P.H. Duesberg, Nature 346, 788 (1990).

325. C. Holden, Science 250, 1514 (1990).

326. P.H. Duesberg, Science 251, 724 (1991).

327. M. Corominas, H. Kamino, J. Leon and A. Pellicer, PNAS 86, 6372 (1989).

328. A. Levan, Ann. N.Y. Acad. Sci. 63, 774 (1956).

329. T.J. Hassold, Trends Genet. 2, 105 (1986).

330. J.J. McCormick and V.M. Maher, Environ. Mol. Mutagen. 14, 105 (1989).

331. C.C. Harris, Cancer Res. 51, 5023 (1991).

332. J.D. Watson, Molecular Biology of the Gene. Benjamin, New York, 1970.

333. P. Rous, Nature 183, 1357 (1959).

334. H. Rubin, JNCI 64, 995 (1980).

335. J. Cairns, Nature 289, 353 (1981).

336. S. Heim and F. Mitelman, Cancer Cytogenetics. Liss, New York, 1987.

337. W. Lijinsky, Environ. Mol. Mutagen. 14, 78 (1989).

338. B.N. Ames, Science 204, 587 (1979).

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